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王濤博士

北京生命科學研究所高級研究員

聯系電話：010-90726675

Tao Wang, Ph.D. Associate Investigator, NIBS, Beijing，China

E-mail：wangtao1006@nibs.ac.cn

教育經歷

Education

2006年美國約翰霍普金斯大學醫學院生物化學系，博士

Ph. D., Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD, USA

2000年北京大學生物化學系，碩士

M.S., Biochemistry Department, Peking University, Beijing, P. R. China

1997年南開大學生物化學及分子生物學系，學士

B.S., Biochemistry and Molecular Biology Department, Nankai University, Tianjin, P. R. China

工作經歷

2018-	北京生命科學研究所高級研究員 Associate Investigator, National Institute of Biological Sciences, Beijing, China
2012-2018	北京生命科學研究所研究員 Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2007-2011	美國Fred Hutchinson癌癥研究中心，博士后 Postdoctoral Fellow, Division of Basic Science Fred Hutchinson Cancer Research Center, Seattle, WA, USA
2006-2007	美國約翰霍普金斯大學，博士后 Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA

研究概述

細胞內各個細胞器包括內質網、線粒體和胞漿都存在質量控制機制，破壞質量控制的任何環節都會影響細胞穩態，是細胞功能喪失。我們的實驗室致力于以果蠅模型為主研究細胞器內質量控制的分子機制；各個質量控制系統之間的協調互作以維持細胞健康。

1. 線粒體運輸協同線粒體自噬維持了神經元軸突中線粒體穩態，對神經元的生長和生理功能維持至關重要。圍繞線粒體的質量控制機制，我們的實驗室致力于揭示線粒體選擇性順行和逆行運輸的分子機制；線粒體自噬及調控網絡，并在果蠅、小鼠、以及人源細胞等多種研究模式中研究線粒體質量控制對神經元生理功能維持的生理意義。

2. 細胞磷脂代謝依賴于線粒體和內質網之間的脂質雙向交換，多種磷脂如磷脂酰乙醇胺的缺乏引起多重應激信號。我們實驗室致力于探索線粒體和內質網之間脂質雙向交換的分子機制和生理功能，進而對細胞器之間如何協同反應以對抗各種壓力。

3. 諸如多聚谷氨酰胺病等主要神經退行性疾病都與錯誤折疊蛋白質的聚集有關。我們實驗室利用胞漿和內質網錯誤折疊蛋白質引發神經元退變的果蠅模型，深入探討細胞如何感知錯誤折疊蛋白質，錯誤折疊蛋白在聚集前和聚集后的清除的機制，以及生物體如何在蛋白高度聚集時引發細胞死亡并清除異常細胞。

發表文章

1. Xie J., Han Y. and Wang T.* 2021. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. PLoS Genet. 17(5):e1009558.

2. Han Y., Zhuang N. and Wang T.* 2021. Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila. Cell Reports. 34(12):108875 (cover article).

3. Xu J., Zhao H. and Wang T.* 2020. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. PLoS Genet. 16(11):e1009172.

4. Zhao H. and Wang T.* 2020. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila. PLoS Genet. 16(10):e1009070.

5. Xiong L., Zhang L., Yang Y., Li N., Lai W., Wang F., Zhu X. and Wang T.*. 2020. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Cell Death Differ. 27(2): 646-661.

6. Xu Y. and Wang T.* 2019. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. Cell Rep. 27(5):1327-1333.

7. Zhao H., Wang J. and Wang T.* 2018. The V-ATPase V1 subunit A1 Is required for rhodopsin anterograde trafficking in Drosophila. Mol. Biol. Cell. 29(13):1640-1651. (cover article).

8. Ren S., Huang Z., Jiang Y. and Wang T.* 2018. dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. J. Cell Biol. 217(2):517-526.

9. Han Y., Xiong L., Xu Y., Tian T. and Wang T.* 2017. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Elife. 6:e29146.

10. Zhuang N., Li L., Chen S. and Wang T.* 2016. PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control. Cell Death Dis. 7(12):e2501.

11. Huang Z., Ren S., Jiang Y. and Wang T.* 2016. PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila. Cell Death Dis. 7:e2179

12. Xu Y. and Wang T.* 2016. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. J Cell Sci. 15;129(2):394-405.

13. Xu Y., An F., Borycz J.A., Borycz J., Meinertzhagen I.A. and Wang T.* 2015. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. PLoS Genet. 11(12):e1005764.

14. Kuo Y., Hang H., Cai T. and Wang T.* 2015. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Sci. Rep. 5:10339.

15. Huang Y., Xie J. and Wang T.* 2015. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS One. 10(12):e0144925.

16. Wu K., Liu J., Zhuang N. and Wang T.* 2014. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. FASEB Journal. 28(12):5111-21

17. Kuo Y., Ren S., Lao U., Edgar B.A., Wang T.* 2013. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death Dis. 3;4:e833.

18. Wang T.*, Blumhagen R., Lao U. Kuo Y. and Edgar B.A. 2012. LST8 regulates cell growth via Target-of-Rapamycin Complex2. Mol. Cell. Biol. 32(12):2203-2213 (cover article).

19. Wang T., WangX., Ni J., Von Lintig J. and Montell C.* 2012. The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. J Neurosci. 32: 3485-3491.

20. Wang X., Wang T., Jiao Y., Von Lintig J. and Montell C.* 2010. Requirement for an Enzymatic Visual Cycle in Drosophila. Curr. Biol. 20:93-102 (equal contribution of first two authors)

21. Wang T.* and Edgar B.A.* 2010. TOR signaling and cell death. The Enzymes. 28: 217-244 (Book Chapter)

22. Wang T., Lao U. and Edgar B.A. 2009. TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J. Cell Biol. 186: 703-711

23. Wang T., Wang X., Xie Q. and Montell C.* 2008. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 57, 56-68 (Cover article).

24. Liu Z., Wang X., Yu Y., Li X., Wang T., Jiang H., Ren Q., Jiao Y., Sawa A., Moran T., Ross CA., Montell C. and Smith W.W.* 2008. A Drosophila model for LRRK2-linked parkinsonism. Proc. Natl. Acad. Sci. USA. 105, 2693-2698

25. Wang T. and Montell C.* 2007. Phototransduction and retinal degeneration in Drosophila. Pflugers Arch. 454, 821-847. (review)

26. Liu C-H. Wang T. Postma M. Obukhov A.G. Montell C. and Hardie R.C.* 2007. In vivo identification and manipulation of the Ca²⁺ selectivity filter in the Drosophila TRP channel. J Neurosci. 27, 604-615 (equal contribution of first two authors).

27. Wang T., Jiao Y. and Montell C.* 2007. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol. 177, 305-316.

28. Wang T. and Montell C.* 2006. A PI Synthase Required for a Sustained Light Response. J Neurosci. 26, 12816-12825.

29. Wang T., Jiao Y. and Montell C.* 2005. Dissecting independent channel and scaffolding roles of the Drosophila TRP channel. J. Cell Biol. 171, 685-694.

30. Wang T. and Montell C.* 2005. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid binding protein. J. Neurosci. 25, 5187-5194 (Cover article).

31. Wang T., Xu H., Oberwinkler J., Gu Y., Hardie R.C. and Montell C.* 2005. Light-activation, adaptation and cell survival functions of the Na⁺/Ca²⁺ exchanger, CalX Neuron 45, 367-378.