蔣輝 博士

北京生命科學研究所高級研究員

Hui Jiang, Ph.D. Associate Investigator, NIBS, Beijing, China

Phone: 010-80726688-8620

Email: jianghui@nibs.ac.cn

教育經歷

Education

2008   博士，中科院上海生命科學研究院神經所

Ph.D.  Institute of Neuroscience, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences

2001   學士，南京大學生物化學系

BS. Biochemistry, Nanjing University, China

工作經歷

Professional Experience

2022-       高級研究員，北京生命科學研究所

Associate Investigator, National Institute of Biological Sciences, Beijing, China

2016-2022    研究員，北京生命科學研究所

Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2011-2016   NIBS fellow, 北京生命科學研究所

NIBS Fellow, National Institute of Biological Sciences, Beijing, China

2008-2011 博士后，德克薩斯大學西南醫學中心王曉東實驗室

Postdoctoral research with Dr. Xiaodong Wang, UT-Southwestern, USA

研究概述

Research Description

線粒體是負責能量供應的細胞器，也是細胞凋亡的關鍵執行者和炎癥反應的重要參與者。線粒體功能紊亂和損傷積累是衰老和衰老相關疾病發生的重要誘因之一。我們實驗室專注于理解線粒體質量控制和穩態維持機制，以及這些機制在退行性疾病和衰老中的作用。我們利用酵母,細胞,小鼠等模型,整合遺傳,生化,化學生物學等手段,研究以下重要問題: 1. 線粒體質量控制體系,包括蛋白質質量控制和線粒體自噬,的分子機理及其生物學功能。2.線粒體疾病,尤其是呼吸鏈損傷相關神經退行性疾病,的致病機理及治療靶點開發。3.線粒體損傷與慢性炎癥和退行性病變的相互關系。

Mitochondrion is the powerhouse of the cell and a key player in apoptosis and inflammation. Mitochondrial dysfunction is a driving force of aging and aging-related degenerative diseases. We exploit yeast, cultured cell, and mouse models to uncover mechanisms surveying mitochondrial quality and maintaining mitochondrial homeostasis. We focus on the following questions: 1. mitochondrial quality control mechanisms, including protein quality control and mitophagy; 2. the pathological mechanisms and therapeutic targets for mitochondrial diseases; 3. the relationship between mitochondrial damage, chronic inflammation, and degenerative diseases.

Research Articles:

1. Sun Y, Cao Y, Wan H, Memetimin A, Cao Y, Li L, Wu C, Wang M, Chen S, Li Q, Ma Y, Dong MQ, Jiang H. A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass. Molecular Cell. 2024 Jan 18;84(2):327-344.

2. Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H.  A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. EMBO Journal. 2023 Mar 10:e113033.

(News and views by Wilhem LP, Ganley IG. Eating your mitochondria-when too much of a good thing turns bad. EMBO J. 2023 Jun 5:e114542.)

3. Yang J, Chen P, Cao Y, Liu S, Wang W, Li L, Li J, Jiang Z, Ma Y, Chen S, Zheng S, Qi X*, Jiang H*. Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell Chem Biol. 2023 Feb 17:S2451-9456(23)00033-8.

4. He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang H. Mitochondrial cristae architecture protects against mtDNA release and inflammation. Cell Reports. 2022 Dec 6; 41(10):111774.

(Recommended by Chandel N: Faculty Opinions Recommendation of [He B et al., Cell Rep 2023 41(10:111774)]. In Faculty Opinions, 13 Feb 2023; 10.3410/f.742441445.793597661)

5. Zheng J, Cao Y, Yang J, Jiang H. UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy. EMBO Reports. 2022 Aug 18:e54859.

6. Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong MQ, Liu Q, Jiang H. Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD⁺ to alleviate mitochondrial diseases. Cell Metabolism. 2021 Oct 5; 33(10):1974-1987.

(Previewed by The Gro3p factor: Restoring NAD⁺/NADH homeostasis to ameliorate mitochondrial disease. Cell Metabolism. 2021 Oct 5;33 (10):1905-1907.)

7. Liu S, Liu S, He B, Li L, Li L, Wang J, Cai T, Chen S, Jiang H. OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. EMBO Reports. 2021 Apr 7; 22(4): e51606.

8. Li L^#, Zheng J^#, Wu X*, Jiang H*. Mitochondrial AAA-ATPase Msp1 detects mislocalized tail-anchored proteins through a dual-recognition mechanism. EMBO Reports. 2019 Apr; 20(4): e46989.

9. Wu X*, Li LL, Jiang H*. (2018). Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45. J Cell Biol. 2018 Jan 2; 217(1):139-149.

10. Wu X*, Li LL, Jiang H*. (2016). Doa1 targets ubiquitinated substrates for mitochondria-associated degradation. J Cell Biol. 2016 Apr 11; 213(1):49-63.

(Commented by Doa1 is a MAD adaptor for Cdc48. J Cell Biol. 2016 Apr 11;213 (1):7-9.)

11. Jiang X, Li L, Ying Z, Pan C, Huang S, Li L, Dai M, Yan B, Li M, Jiang H, Chen S, Zhang Z, Wang X (2016). A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway. Mol Cell. 2016 Jul 21;63(2):229-39.

12. Jiang X, Jiang H, Shen Z, Wang X. (2014). Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14782-7.

13. Wang Z, Jiang H, Chen S, Du F, Wang X. (2012). The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012 Jan 20;148(1-2):228-43.

14. Guo W, Jiang H, Gray V, Dedhar S, Rao Y (2007). Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Dev Biol. 306:457-68.

15. Ward ME, Jiang H, Rao Y (2005). Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration. Mol Cell Neurosci 30:378-87.

16. Jiang H, Guo W, Liang X, Rao Y (2005). Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell 120:123-35.

(Highlighted by Science, Nature Review Neuroscience, and Current Biology)

# co-first author, * co-corresponding author.

Reviews and Comments

17. Sun Y, Jiang H. Meet the Authors: Yuqiu Sun and Hui Jiang. Mol Cell. 2024 Jan 18;84(2):183-185. doi: 10.1016/j.molcel.2023.12.030.

18. Liu S, Liu S, Jiang H. Multifaceted roles of mitochondrial stress responses under ETC dysfunction - repair, destruction and pathogenesis. FEBS J. 2022 Nov;289(22):6994-7013. doi: 10.1111/febs.16323.

19. Jiang H. Quality control pathways of tail-anchored proteins. BBA Mol Cell Res. 2021 Feb;1868(2):118922.

20. Zheng J, Li L, Jiang H. Molecular pathways of mitochondrial outer membrane protein degradation. Biochem Soc Trans. 2019 Oct 31; 47(5):1437-1447.

21. Jiang H, Rao Y (2005). Axon formation: fate versus growth. Nat Neurosci. 8:544-6.