李超博士

北京生命科學研究所高級研究員

Chao Li, Ph.D. Associate Investigator, NIBS, Beijing, China

Phone: 86-10-80726688

Fax: 86-10-80726689

E-mail: lichao@nibs.ac.cn

實驗室主頁：http://www.lichaolab.com

教育經(jīng)歷 Education

2013 北京生命科學研究所與天津大學聯(lián)合培養(yǎng)有機合成化學博士

Ph.D. in Organic Synthesis, National Institute of Biological Science (NIBS), Beijing & Tianjin University, Tianjin, China.

2008 青島科技大學制藥工程學士

B.S., Pharmaceutical Engineering, Qingdao University of Science and Technology, Qingdao, China

研究概述 Research Description

化學小分子在認知，干擾與調節(jié)生物過程中發(fā)揮著重要的作用。我們課題組致力于在開拓合成化學空間的基礎上，利用獲得的活性小分子發(fā)現(xiàn)與人類重大疾病相關的藥物作用靶標和先導化合物。同時設計合成具有重要生物學利用價值的化學工具分子。具體的研究內容包括：

（1）利用新型催化體系研究新穎的化學鍵構建方法，為化學分子的合成提供更理想的策略。

（2）選擇與重大疾病相關的天然產(chǎn)物進行合成及活性優(yōu)化，進而推動創(chuàng)新藥物的研究;

（3）探索活性天然小分子的生物學作用機制和其作用靶標;

（4）設計合成能夠選擇性標記，追蹤生物大分子或識別其相互作用的化學工具分子。

我們實驗室誠摯地歡迎想利用化學手段解決生物學問題的科學家加入。

Small molecules are of paramount importance in the recognition, modulation and regulation of biological processes. The research of our group explores the interface between chemical synthesis and biology, by pursuing the efficient synthesis of structurally novel and therapeutically potent small molecules prior to probing their mechanism of action and functional targets. Our specific research interests include the following:

? Development of new catalytic reactions for the efficient construction of chemical bonds, thereby providing practical synthetic methods for “ideal synthesis”.

? Total synthesis of structurally complex and bioactive natural products.

? Exploring the mechanism of action and the functional targets of bioactive small molecules.

? Development of novel molecular probes to study the interactions between biological macromolecules.

代表文章Representative Publications

19. Li, Z.; Sun, W.; Wang, X.; Li, L; Zhang, Y.; Li, C.* “Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides” J. Am. Chem. Soc. 2021, 143, 3536-3543.

18. Xu, G.#; Wu, J.#; Li, L.; Lu, Y.; Li, C.* “Total Synthesis of (-)-Daphnezomines A and B” J. Am. Chem. Soc. 2020, 142, 15240-15245.

17. Zhuo, J.#; Zhang, Y.#; Li, Z.; Li, C.* “Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles”. ACS Catal. 2020, 10, 3895-3903.

16.Zhang, J.#; Li, Z.#; Zhuo, J.; Cui, Y.; Han, T.; Li, C.* “Tandem Decarboxylative     Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin” J. Am. Chem. Soc. 2019, 141, 8372-8380.

15. Li, C.#; Kawamata, Y.#; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Star, J. T.; Chen, J.; Yan, M.; Baran, P. S.* “Electrochemically Enabled, Ni-Catalyzed Amination” Angew. Chem. Int. Ed. 2017, in press

14. Li, C.^#; Wang, J.^#; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.* “Decarboxylative Borylation” Science, 2017, 356, 1045.

13. Qin, T.^#; Cornella, J.^#; Li, C.^#; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S.* “A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents” Science 2016, 352, 801-805

12. Li, C.; Jones, A. X.; Lei, X.* “Synthesis and Mode of Action of Oligomeric Sesquiterpene Lactones” Nat. Prod. Rep. 2016, 33, 602-611.

11. Li, D.^#; Li, C.^#; Li, L.; Chen, S.; Wang, L.; Li, Q.; Wang, X.; Lei, X.*; Shen, Z.* “Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis” Cell Chemical Biology 2016, 23, 257-266.

10. Hong, B.^#; Li, C.^#; Wang, Z.; Chen, J.; Li, H.*; Lei, X.* “Enantioselective Total Synthesis of (?)-Incarviatone A” J. Am. Chem. Soc. 2015, 137, 11946-11949.

9. Dao, H. T.; Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S.* “Hydromethylation of Unactivated Olefins” J. Am. Chem. Soc. 2015, 137, 8046-8049.

8. Dong, T. ^#; Li, C. ^#; Wang, X.; Dian, L.; Zhang, X.; Li, L.; Chen, S.; Cao, R.; Li, L.; Huang, N.; He, S.;* Lei, X.* “Ainsliadimer A Selectively Inhibits IKKα/β by Covalently Binding a Conserved Cysteine” Nature Commun. 2015, 6, 6522.

7. Li, C.^#; Dong, T.^#; Li, Q.; Lei, X.* “Probing the Anticancer Mechanism of (?)-Ainsliatrimer?A through Diverted Total Synthesis and Bioorthogonal Ligation” Angew. Chem. Int. Ed. 2014, 53, 12111-12115.

6. Li, C.; Lei, X.* “Strategies toward the Biomimetic Syntheses of Oligomeric Sesquiterpenoids” J. Org. Chem. 2014, 79, 3289-3295.

5. Li, C.; Dong, T.; Dian, L.; Zhang, W.; and Lei, X.* “Biomimetic Syntheses and Structural Elucidation of the Apoptosis-Inducing Sesquiterpenoid Trimers: (-)-Ainsliatrimers A and B” Chem. Sci. 2013,4, 1163-1167.

4. Li, C.; Li, X.; Wang, X.; Lei, X.* “Diversity-oriented Synthesis of Bicyclic Ring Systems via a Conjugate Addition/aldol/RCM Process” Sci. China. Chem. 2013, 56, 337-341.

3. Li, C.; Dian, L.; Zhang, W.; Lei, X.* “Biomimetic Syntheses of (-)-Gochnatiolides A-C and (-)-Ainsliadimer B” J. Am. Chem. Soc. 2012, 134, 12414-12417.

2. Li, C.; Tu, S.; Wen, S.; Li, S.; Chang, J.; Shao, F, Lei, X.* “Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C” J. Org. Chem. 2011, 76, 3566-3570.

1. Li, C.; Yu, X.; Lei, X.* “A Biomimetic Total Synthesis of (+)-Ainsliadimer A” Org. Lett. 2010, 12, 4284-4287.

專利Patents

1. Lei, X.; He, S.; Li, C.; Dong, T. “Sesquiterpenoids” PCT/CN2014/076123. US Pat No. 9670226.

2. Baran, P. S.; Li, C.; Wang, J.; Chatterjee, A. K.; Kumar, M.; Yu, S.; Johnson, K. A.; “Decarboxylative Borylation” under review.