Tao Cai, Ph.D.

Director， Sequencing Center

NIBS, Beijing

tel：010-80726688-8880

Room Number: B027

E-mail: caitao@nibs.ac.cn

Education

2006年 北京大學(xué)生物信息學(xué)博士

Ph.D.  Bioinformatics, Peking University, China

2001年 北京大學(xué)生理學(xué)及生物物理學(xué)學(xué)士

B.S.  Physiology & Biophysics, Peking University，China

Professional Experience

2010年- 北京生命科學(xué)研究所測序中心主任

Director, Sequencing Center, National Institute of Biological Sciences, Beijing, China

2008-2010年 博士后， 洛桑中心醫(yī)院，瑞士

Postdoctoral Researcher, Lausanne University Hospital (CHUV), Switzerland

2006-2008年 博士后，北京生命科學(xué)研究所

Postdoctoral Researcher, National Institute of Biological Sciences, Beijing, China

Research Description

Sequencing technology is widely used in basic researches and translational studies. The state-of-the-art sequencing technology can provide great amount of information for the composition, variation, interaction, regulation and modification of DNA or RNA. Our lab is equipped with the advanced next-generation sequencing (NGS) platform, single cell library preparation system and high performance computation system. Our research focuses on developing new NGS technology, exploring new NGS application and understanding huge mass of sequencing data.

代表性論文：

1.      Wang Y.; Tang Z.; Huang H.; Li J.; Wang Z.; Yu Y.; Zhang C.; Dai H.; Wang F.; Cai T.*, and Tang N.*, Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. Proc Natl Acad Sci U S A, 2018. * co-corresponding authors

2.      Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T*, and Gao S*. Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming. Cell Stem Cell, doi.org/10.1016/j.stem.2013.02.005, Mar.14, 2013 *co-corresponding authors

3. Cai T, J.F. Dufour, B. Muellhaupt, T. Gerlach, M. Heim, D. Moradpour, A. Cerny, R. Malinverni, V. Kaddai, M. Bochud, et al., Viral Genotype-Specific Role of PNPLA3, PPARG, MTTP and IL28B in Hepatitis C Virus-Associated Steatosis. J Hepatol, 2011.

4.      Rauch, A.*, Z. Kutalik*, P. Descombes*, Cai T, J. Di Iulio, T. Mueller, M. Bochud, M. Battegay, E. Bernasconi, J. Borovicka, et al., Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology, 2010. 138(4): p. 1338-45, 1345 e1-7.

5.      Mi, S.*, Cai T*, Y. Hu, Y. Chen, E. Hodges, F. Ni, L. Wu, S. Li, H. Zhou, C. Long, et al., Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell, 2008. 133(1): p. 116-27. * co-first authors